Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 47 Researches
8
USERS' SCORE
Good
Based on 3 Reviews
8.4
Supplement Facts
Serving Size: One (1) Capsule
Amount Per Serving
%DV
Calories
0
Total Carbohydrate
0 g
0%+
Total Sugars
0 g
**
Incl. 0 g Added Sugars
0%+
Lactobacillus rhamnosus GG
40 mg (10 billion CFUs)
**
Inulin (Chicory Root Extract)
200 mg
**
Top Medical Research Studies
8
Our analysis focused on evaluating the cholesterol-lowering capabilities of Lactobacillus acidophilus strain AM13-1, isolated from a healthy individual.
We observed that this strain demonstrated a significant ability to remove cholesterol with a remarkable efficiency rate of 70%.
Additionally, the genome of AM13-1 revealed beneficial characteristics, including a lack of harmful factors and several probiotic-related genes.
However, our findings indicate that while the strain shows promise, more in-depth research is necessary to establish its practical benefits in everyday health.
We observed that this strain demonstrated a significant ability to remove cholesterol with a remarkable efficiency rate of 70%.
Additionally, the genome of AM13-1 revealed beneficial characteristics, including a lack of harmful factors and several probiotic-related genes.
However, our findings indicate that while the strain shows promise, more in-depth research is necessary to establish its practical benefits in everyday health.
Read More
9
We explored the effectiveness of the probiotic strain CCFM1376 in managing high cholesterol in mice. Through a controlled study, mice were fed a high-cholesterol diet alongside CCFM1376 for eight weeks.
Results showed that CCFM1376 led to lower total and LDL cholesterol levels, while boosting HDL cholesterol. The strain also increased the presence of beneficial bile acids in the body. These findings suggest that CCFM1376 may be a promising probiotic approach for improving cholesterol levels.
Results showed that CCFM1376 led to lower total and LDL cholesterol levels, while boosting HDL cholesterol. The strain also increased the presence of beneficial bile acids in the body. These findings suggest that CCFM1376 may be a promising probiotic approach for improving cholesterol levels.
Read More
9
Lactobacillus postbiotics reduce cholesterol
We examined how postbiotics from Lactobacillus species could help lower cholesterol levels. Using both in vitro and in vivo studies, we found that yogurt fortified with these postbiotics led to notable reductions in total cholesterol, triglycerides, and LDL levels in Wistar rats on a high-cholesterol diet.
Not only did the yogurt show significant antioxidant and antibacterial benefits, but these results also indicate that such functional foods could be a meaningful approach for managing cholesterol and protecting against foodborne pathogens.
Not only did the yogurt show significant antioxidant and antibacterial benefits, but these results also indicate that such functional foods could be a meaningful approach for managing cholesterol and protecting against foodborne pathogens.
Read More
Most Useful Reviews
9
Improved digestion
1 people found this helpful
This nutritional supplement has greatly helped my digestion. After suffering from diarrhea, I noticed improvement within 10 days of taking the tablets. I found that taking them on an empty stomach an hour before meals enhanced absorption. Overall, my discomfort in the intestines has improved, and I appreciate the product's support in managing my high cholesterol.
Read More
7.5
Cholesterol reduction
4 people found this helpful
Contains inulin, which is both a probiotic and a prebiotic. Inulin helps to normalise the gastrointestinal tract and promotes beneficial microorganisms, reducing the chances of constipation. It also aids in lowering cholesterol levels by reducing liver enzyme production of fats and enhancing the elimination of cholesterol from the body. Additionally, it supports appetite control and weight loss.
Read More
7.5
Probiotic benefits
1 people found this helpful
This excellent product serves as both a probiotic and a prebiotic, distinguishing it from others. While its price is a drawback, I appreciate its effectiveness, particularly in relation to managing high cholesterol levels.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 47 Researches
8
- All Researches
9
We explored the effectiveness of the probiotic strain CCFM1376 in managing high cholesterol in mice. Through a controlled study, mice were fed a high-cholesterol diet alongside CCFM1376 for eight weeks.
Results showed that CCFM1376 led to lower total and LDL cholesterol levels, while boosting HDL cholesterol. The strain also increased the presence of beneficial bile acids in the body. These findings suggest that CCFM1376 may be a promising probiotic approach for improving cholesterol levels.
Results showed that CCFM1376 led to lower total and LDL cholesterol levels, while boosting HDL cholesterol. The strain also increased the presence of beneficial bile acids in the body. These findings suggest that CCFM1376 may be a promising probiotic approach for improving cholesterol levels.
Read More
9
Lactobacillus postbiotics reduce cholesterol
We examined how postbiotics from Lactobacillus species could help lower cholesterol levels. Using both in vitro and in vivo studies, we found that yogurt fortified with these postbiotics led to notable reductions in total cholesterol, triglycerides, and LDL levels in Wistar rats on a high-cholesterol diet.
Not only did the yogurt show significant antioxidant and antibacterial benefits, but these results also indicate that such functional foods could be a meaningful approach for managing cholesterol and protecting against foodborne pathogens.
Not only did the yogurt show significant antioxidant and antibacterial benefits, but these results also indicate that such functional foods could be a meaningful approach for managing cholesterol and protecting against foodborne pathogens.
Read More
9
We investigated how Lactobacillus ATCC8014 affects high cholesterol in postmenopausal mice. By feeding female mice a high-fat diet and administering Lactobacillus for 13 weeks, we saw a significant reduction in total cholesterol and triglycerides.
This improvement was linked to increased excretion of secondary bile acids, which in turn helps to convert cholesterol. Our study suggests that Lactobacillus may offer therapeutic benefits for managing cholesterol levels in postmenopausal women through changes in gut bacteria and bile acid metabolism.
This improvement was linked to increased excretion of secondary bile acids, which in turn helps to convert cholesterol. Our study suggests that Lactobacillus may offer therapeutic benefits for managing cholesterol levels in postmenopausal women through changes in gut bacteria and bile acid metabolism.
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9
We focused on how microencapsulating Lactobacillus plantarum LAB12 could help maintain its cholesterol-lowering benefits. By using a combination of alginate and pea protein, we created a protective environment for the probiotics.
This method not only improved the survival of LAB12 under harsh conditions but also showed promising results in lowering serum triglycerides and increasing HDL cholesterol in zebrafish with high cholesterol diets.
Overall, our findings suggest that microencapsulation could enhance the effectiveness of this probiotic in promoting heart health.
This method not only improved the survival of LAB12 under harsh conditions but also showed promising results in lowering serum triglycerides and increasing HDL cholesterol in zebrafish with high cholesterol diets.
Overall, our findings suggest that microencapsulation could enhance the effectiveness of this probiotic in promoting heart health.
Read More
9
We evaluated how Lactobacillus NCIMB (LRC™) affects high cholesterol by testing it on rats and liver cells.
Our research discovered that LRC can lower cholesterol levels by hampering the production of cholesterol in cells and enhancing cholesterol excretion through the intestines.
Notably, LRC effectively inhibited important enzymes and improved cholesterol transport. In essence, it appears that leveraging LRC could be a promising way to help manage cholesterol levels effectively.
Our research discovered that LRC can lower cholesterol levels by hampering the production of cholesterol in cells and enhancing cholesterol excretion through the intestines.
Notably, LRC effectively inhibited important enzymes and improved cholesterol transport. In essence, it appears that leveraging LRC could be a promising way to help manage cholesterol levels effectively.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Improved digestion
1 people found this helpful
This nutritional supplement has greatly helped my digestion. After suffering from diarrhea, I noticed improvement within 10 days of taking the tablets. I found that taking them on an empty stomach an hour before meals enhanced absorption. Overall, my discomfort in the intestines has improved, and I appreciate the product's support in managing my high cholesterol.
Read More
7.5
Cholesterol reduction
4 people found this helpful
Contains inulin, which is both a probiotic and a prebiotic. Inulin helps to normalise the gastrointestinal tract and promotes beneficial microorganisms, reducing the chances of constipation. It also aids in lowering cholesterol levels by reducing liver enzyme production of fats and enhancing the elimination of cholesterol from the body. Additionally, it supports appetite control and weight loss.
Read More
7.5
Probiotic benefits
1 people found this helpful
This excellent product serves as both a probiotic and a prebiotic, distinguishing it from others. While its price is a drawback, I appreciate its effectiveness, particularly in relation to managing high cholesterol levels.
Read More
Frequently Asked Questions
9
Improved digestion
1 people found this helpful
This nutritional supplement has greatly helped my digestion. After suffering from diarrhea, I noticed improvement within 10 days of taking the tablets. I found that taking them on an empty stomach an hour before meals enhanced absorption. Overall, my discomfort in the intestines has improved, and I appreciate the product's support in managing my high cholesterol.
7.5
Cholesterol reduction
4 people found this helpful
Contains inulin, which is both a probiotic and a prebiotic. Inulin helps to normalise the gastrointestinal tract and promotes beneficial microorganisms, reducing the chances of constipation. It also aids in lowering cholesterol levels by reducing liver enzyme production of fats and enhancing the elimination of cholesterol from the body. Additionally, it supports appetite control and weight loss.
7.5
Probiotic benefits
1 people found this helpful
This excellent product serves as both a probiotic and a prebiotic, distinguishing it from others. While its price is a drawback, I appreciate its effectiveness, particularly in relation to managing high cholesterol levels.
7
We investigated the impact of two probiotic strains, Lactobacillus rhamnosus BFE5264 and Lactiplantibacillus plantarum NR74, on high cholesterol levels in a murine model. The results indicated that these probiotics help reduce cholesterol absorption in the intestines and support liver metabolism.
Specifically, L. rhamnosus was particularly effective in boosting cholesterol processing in the liver. However, as this study focused on animal models, more research is needed to confirm these findings in humans.
Overall, these probiotics show promise for managing diet-related hypercholesterolemia.
Specifically, L. rhamnosus was particularly effective in boosting cholesterol processing in the liver. However, as this study focused on animal models, more research is needed to confirm these findings in humans.
Overall, these probiotics show promise for managing diet-related hypercholesterolemia.
7
Inulin's potential to lower cholesterol
We conducted a systematic review and meta-analysis to explore the effects of inulin-type fructans (ITF) on cardiovascular disease risk factors, particularly focusing on cholesterol levels. The research carefully examined several randomized controlled trials where participants received either ITF supplements or placebo treatments for at least two weeks.
Our findings indicated that ITF supplementation may help reduce levels of low-density lipoprotein (LDL) cholesterol and triglycerides, along with supporting weight loss. However, it’s important to note that the certainty of these findings was rated as low to very low, suggesting that we need more robust studies before drawing firm conclusions.
Our exploration into the effects of inulin on cholesterol levels reveals some promising benefits, but also highlights the need for further research. It’s clear that more well-designed trials are essential to confirm these effects on cardiovascular health.
Our findings indicated that ITF supplementation may help reduce levels of low-density lipoprotein (LDL) cholesterol and triglycerides, along with supporting weight loss. However, it’s important to note that the certainty of these findings was rated as low to very low, suggesting that we need more robust studies before drawing firm conclusions.
Our exploration into the effects of inulin on cholesterol levels reveals some promising benefits, but also highlights the need for further research. It’s clear that more well-designed trials are essential to confirm these effects on cardiovascular health.
8
We explored the effectiveness of a food supplement containing glucomannan, D-chiro-inositol, blume, and inulin on high cholesterol levels in individuals with metabolic syndrome and type 2 diabetes or impaired glucose tolerance. In a well-structured study, fifty-eight participants were randomly assigned to take this supplement daily for four months, in combination with metformin.
Upon analysis of the results after 16 weeks, we observed notable improvements. Specifically, there was a significant reduction in total serum cholesterol levels, triglycerides, and LDL cholesterol, which are critical for managing heart health.
However, while this study demonstrated positive outcomes associated with the complete supplement, it limits our ability to isolate the specific impact of inulin on cholesterol alone. That said, inulin, as a part of this blend, contributes positively to lipid profiles when combined with other active ingredients and treatments.
Upon analysis of the results after 16 weeks, we observed notable improvements. Specifically, there was a significant reduction in total serum cholesterol levels, triglycerides, and LDL cholesterol, which are critical for managing heart health.
However, while this study demonstrated positive outcomes associated with the complete supplement, it limits our ability to isolate the specific impact of inulin on cholesterol alone. That said, inulin, as a part of this blend, contributes positively to lipid profiles when combined with other active ingredients and treatments.
9
We investigated the cholesterol-lowering effects of two specific probiotic strains, FM9 and Y57, using a high-fat diet model in male Wistar rats. Over 30 days, these strains demonstrated a significant ability to improve blood lipid profiles.
Notably, FM9 and Y57 reduced serum cholesterol levels by 9% and 8%, respectively, while also improving "good" HDL cholesterol levels more than the statin treatment.
These results suggest that probiotics like FM9 and Y57 may offer a natural alternative to conventional medications for managing cholesterol, with the potential for anti-obesity benefits too, though clinical trials are needed to confirm these effects in humans.
Notably, FM9 and Y57 reduced serum cholesterol levels by 9% and 8%, respectively, while also improving "good" HDL cholesterol levels more than the statin treatment.
These results suggest that probiotics like FM9 and Y57 may offer a natural alternative to conventional medications for managing cholesterol, with the potential for anti-obesity benefits too, though clinical trials are needed to confirm these effects in humans.
References
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- Chen Y, Zheng K, Leng Y, Zhang Z, Li X, et al. Alleviating effect of E15 on hyperlipidemia and hepatic lipid metabolism in zebrafish fed by a high-fat diet through the production of short-chain fatty acids. Front Nutr. 2025;12:1522982. doi:10.3389/fnut.2025.1522982
- Akbal S, Uğur Geçer E, Ertürkmen P. Probiotic Viability and Bioactive Properties of Buffalo Yoghurt Produced Using High Cholesterol-Assimilating Probiotic Strains. Vet Med Sci. 2025;11:e70233. doi:10.1002/vms3.70233
- Davarzani S, Sanjabi MR, Mojgani N, Mirdamadi S, Soltani M. Investigating the Antibacterial, Antioxidant, and Cholesterol-lowering Properties of Yogurt Fortified with Postbiotic of Lactobacillus acidophilus and Lactiplantibacillus plantarum in the Wistar Rat Model. J Food Prot. 2024;87:100408. doi:10.1016/j.jfp.2024.100408
- Dang L, Li D, Mu Q, Zhang N, Li C, et al. Youth-derived Lactobacillus rhamnosus with prebiotic xylo-oligosaccharide exhibits anti-hyperlipidemic effects as a novel synbiotic. Food Res Int. 2024;195:114976. doi:10.1016/j.foodres.2024.114976
- Nuankham K, Sitdhipol J, Chonpathompikunlert P, Khongrum J, Kittichaiworakul R, et al. Impact of () sup. TISTR 2593 Probiotic Supplementation on the Gut Microbiome of Hypercholesterolemia Patients: A Randomized Controlled Trial. Nutrients. 2024;16. doi:10.3390/nu16172916
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- Zhao K, Qiu L, He Y, Tao X, Zhang Z, et al. Alleviation Syndrome of High-Cholesterol-Diet-Induced Hypercholesterolemia in Mice by Intervention with WLPL21 via Regulation of Cholesterol Metabolism and Transportation as Well as Gut Microbiota. Nutrients. 2023;15. doi:10.3390/nu15112600
- Lacroix S, Leblanc N, Abolghasemi A, Paris-Robidas S, Martin C, et al. Probiotic interventions promote metabolic health in high fat-fed hamsters in association with gut microbiota and endocannabinoidome alterations. Benef Microbes. 2023;14:223. doi:10.3920/BM2022.0080
- Aziz M, Hemeda SA, Albadrani GM, Fadl SE, Elgendey F. Ameliorating effect of probiotic on nonalcoholic fatty liver disease and lipolytic gene expression in rabbits. Sci Rep. 2023;13:6312. doi:10.1038/s41598-023-32584-7
- Khongrum J, Yingthongchai P, Boonyapranai K, Wongtanasarasin W, Aobchecy P, et al. Safety and Effects of TISTR 2593 Supplementation on Improving Cholesterol Metabolism and Atherosclerosis-Related Parameters in Subjects with Hypercholesterolemia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Nutrients. 2023;15. doi:10.3390/nu15030661
- Çiftci G, Çiftci A, Onuk B, Çenesiz M, Savaşan S, et al. Investigation of the effects of atorvastatin and Lactobacillus acidophilus on some hormones and oxidative stress in experimental hypercholesterolemia. Prostaglandins Other Lipid Mediat. 2023;165:106716. doi:10.1016/j.prostaglandins.2023.106716
- Correia Gomes D, Meza Alvarado JE, Zamora Briseño JA, Cano Sarmiento C, Camacho Morales A, et al. Maternal Supplementation with GG Improves Glucose Tolerance and Modulates the Intestinal Microbiota of Offspring. Diseases. 2024;12. doi:10.3390/diseases12120312
- Papakonstantinou E, Zacharodimos N, Georgiopoulos G, Athanasaki C, Bothou DL, et al. Two-Month Consumption of Orange Juice Enriched with Vitamin D3 and Probiotics Decreases Body Weight, Insulin Resistance, Blood Lipids, and Arterial Blood Pressure in High-Cardiometabolic-Risk Patients on a Westernized Type Diet: Results from a Randomized Clinical Trial. Nutrients. 2024;16. doi:10.3390/nu16091331
- Negm El-Dein A, Ezzat A, Aly HF, Awad G, Farid M. Lactobacillus-fermented yogurt exerts hypoglycemic, hypocholesterolemic, and anti-inflammatory activities in STZ-induced diabetic Wistar rats. Nutr Res. 2022;108:22. doi:10.1016/j.nutres.2022.10.003
- Zafar H, Ain NU, Alshammari A, Alghamdi S, Raja H, et al. FM9 and Y57 Are as Effective as Statins at Improving Blood Lipid Profile in High Cholesterol, High-Fat Diet Model in Male Wistar Rats. Nutrients. 2022;14. doi:10.3390/nu14081654
- Yoon H, Lee Y, Kang HJ, Ju J, Ji Y, et al. Two putative probiotic strains improve diet-induced hypercholesterolemia through modulating intestinal cholesterol uptake and hepatic cholesterol efflux. J Appl Microbiol. 2022;132:562. doi:10.1111/jam.15181
- Daliri EB, Kim Y, Do Y, Chelliah R, Oh DH. In Vitro and In Vivo Cholesterol Reducing Ability and Safety of Probiotic Candidates Isolated from Korean Fermented Soya Beans. Probiotics Antimicrob Proteins. 2022;14:87. doi:10.1007/s12602-021-09798-0
- Lee CS, Park MH, Kim BK, Kim SH. Antiobesity Effect of Novel Probiotic Strains in a Mouse Model of High-Fat Diet-Induced Obesity. Probiotics Antimicrob Proteins. 2021;13:1054. doi:10.1007/s12602-021-09752-0
- El-Dein AN, Nour El-Deen AM, El-Shatoury EH, Awad GA, Ibrahim MK, et al. Assessment of exopolysaccharides, bacteriocins and in vitro and in vivo hypocholesterolemic potential of some Egyptian Lactobacillus spp. Int J Biol Macromol. 2021;173:66. doi:10.1016/j.ijbiomac.2021.01.107
- Das S, Mishra BK, Hati S. Techno-functional characterization of indigenous isolates from the traditional fermented foods of Meghalaya, India. Curr Res Food Sci. 2020;3:9. doi:10.1016/j.crfs.2020.01.002
- Romão da Silva LF, de Oliveira Y, de Souza EL, de Luna Freire MO, Braga VA, et al. Effects of probiotic therapy on cardio-metabolic parameters and autonomic modulation in hypertensive women: a randomized, triple-blind, placebo-controlled trial. Food Funct. 2020;11:7152. doi:10.1039/d0fo01661f
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- Jawad I, Bin Tawseen H, Irfan M, Ahmad W, Hassan M, et al. Dietary Supplementation of Microbial Dextran and Inulin Exerts Hypocholesterolemic Effects and Modulates Gut Microbiota in BALB/c Mice Models. Int J Mol Sci. 2023;24. doi:10.3390/ijms24065314
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- Kismiati S, Djauhari L, Sunarti D, Sarjana TA. Effects of synbiotics preparations added to Pengging duck diets on egg production and egg quality and hematological traits. Vet World. 2022;15:878. doi:10.14202/vetworld.2022.878-884
- Bandyopadhyay B, Das S, Mitra PK, Kundu A, Mandal V, et al. Characterization of two new strains of Lactococcus lactis for their probiotic efficacy over commercial synbiotics consortia. Braz J Microbiol. 2022;53:903. doi:10.1007/s42770-022-00685-6
- Wang Y, Nan X, Zhao Y, Jiang L, Wang H, et al. Dietary supplementation with inulin improves lactation performance and serum lipids by regulating the rumen microbiome and metabolome in dairy cows. Anim Nutr. 2021;7:1189. doi:10.1016/j.aninu.2021.09.007
- Li L, Li P, Xu L. Assessing the effects of inulin-type fructan intake on body weight, blood glucose, and lipid profile: A systematic review and meta-analysis of randomized controlled trials. Food Sci Nutr. 2021;9:4598. doi:10.1002/fsn3.2403
- Uthan ET, Senturk H, Uyanoglu M, Yamaç M. First Report on the In Vivo Prebiotic, Biochemical, and Histological Effects of Crude Polysaccharide Fraction of Golden Chantharelle Mushroom, Cantharellus cibarius (Agaricomycetes). Int J Med Mushrooms. 2021;23:67. doi:10.1615/IntJMedMushrooms.2021038233
- Bandyopadhyay B, Mandal V, Mandal NC. Partial characterization of novel inulin-like prebiotic fructooligosaccharides of Sechium edule (Jacq.) Sw. (Cucurbitaceae) tuberous roots. J Food Biochem. 2021;45:e13764. doi:10.1111/jfbc.13764
- Vázquez-Manjarrez N, Guevara-Cruz M, Flores-López A, Pichardo-Ontiveros E, Tovar AR, et al. Effect of a dietary intervention with functional foods on LDL-C concentrations and lipoprotein subclasses in overweight subjects with hypercholesterolemia: Results of a controlled trial. Clin Nutr. 2021;40:2527. doi:10.1016/j.clnu.2021.02.048
